Using CRC-specific mortality data from 3,036 U.S. counties from 1999 to 2019, researchers at the Lerner Research Institute and the Center for Young-Onset Colorectal Cancer at Cleveland Clinic categorized patients by age at diagnosis and adjusted for young-onset CRC risk factors and prognostic indicators. They identified new young-onset CRC mortality hot spots in the Midwest and northeastern Great Lakes region and cold spots in western and southwestern counties, which have a lower risk for young-onset CRC mortality.